Elimination of New Chronic Hepatitis B Virus Infections: Results of the Alaska Immunization Program
Identifieur interne : 001B35 ( Main/Exploration ); précédent : 001B34; suivant : 001B36Elimination of New Chronic Hepatitis B Virus Infections: Results of the Alaska Immunization Program
Auteurs : Rafael Harpaz [Géorgie (pays)] ; Brian J. Mcmahon ; Harold S. Margolis [Géorgie (pays)] ; Craig N. Shapiro [Géorgie (pays)] ; Dean Havron ; Gina Carpenter ; Lisa R. Bulkow [Géorgie (pays)] ; Robert B. Wainwright [Géorgie (pays)]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2000-02.
Abstract
An immunization assessment and a serologic survey were conducted to evaluate the effectiveness of a hepatitis B immunization program in eliminating hepatitis B virus (HBV) transmission among Alaska Natives in a region in which HBV infection is endemic. Hepatitis B vaccine coverage was 93% among 567 children ⩽10 years old residing in the study villages, and catch-up vaccine coverage among 582 susceptible persons 11–30 years old was 62%. None of 271 tested children ⩽10 years old were chronically infected with HBV, and just 4 (1.5%) had evidence of resolved infection. In contrast, 16% of 332 persons 11–30 years old (those born before implementation of routine infant hepatitis B vaccination) were chronically infected. A hepatitis B immunization program that includes prevention of perinatal HBV infection, routine infant vaccination, and catch-up vaccination of older children and adults can eliminate new chronic HBV infections in a population with a high rate of chronic infection.
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DOI: 10.1086/315259
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Bulkow</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Wainwright, Robert B" sort="Wainwright, Robert B" uniqKey="Wainwright R" first="Robert B." last="Wainwright">Robert B. Wainwright</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2000-02">2000-02</date><biblScope unit="volume">181</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="413">413</biblScope><biblScope unit="page" to="418">418</biblScope></imprint><idno type="ISSN">0022-1899</idno></series><idno type="istex">880F36015B342039B5430C7D61352510721215CB</idno><idno type="DOI">10.1086/315259</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">An immunization assessment and a serologic survey were conducted to evaluate the effectiveness of a hepatitis B immunization program in eliminating hepatitis B virus (HBV) transmission among Alaska Natives in a region in which HBV infection is endemic. Hepatitis B vaccine coverage was 93% among 567 children ⩽10 years old residing in the study villages, and catch-up vaccine coverage among 582 susceptible persons 11–30 years old was 62%. None of 271 tested children ⩽10 years old were chronically infected with HBV, and just 4 (1.5%) had evidence of resolved infection. In contrast, 16% of 332 persons 11–30 years old (those born before implementation of routine infant hepatitis B vaccination) were chronically infected. A hepatitis B immunization program that includes prevention of perinatal HBV infection, routine infant vaccination, and catch-up vaccination of older children and adults can eliminate new chronic HBV infections in a population with a high rate of chronic infection.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li></country></list><tree><noCountry><name sortKey="Carpenter, Gina" sort="Carpenter, Gina" uniqKey="Carpenter G" first="Gina" last="Carpenter">Gina Carpenter</name><name sortKey="Havron, Dean" sort="Havron, Dean" uniqKey="Havron D" first="Dean" last="Havron">Dean Havron</name><name sortKey="Mcmahon, Brian J" sort="Mcmahon, Brian J" uniqKey="Mcmahon B" first="Brian J." last="Mcmahon">Brian J. Mcmahon</name></noCountry><country name="Géorgie (pays)"><noRegion><name sortKey="Harpaz, Rafael" sort="Harpaz, Rafael" uniqKey="Harpaz R" first="Rafael" last="Harpaz">Rafael Harpaz</name></noRegion><name sortKey="Bulkow, Lisa R" sort="Bulkow, Lisa R" uniqKey="Bulkow L" first="Lisa R." last="Bulkow">Lisa R. Bulkow</name><name sortKey="Margolis, Harold S" sort="Margolis, Harold S" uniqKey="Margolis H" first="Harold S." last="Margolis">Harold S. Margolis</name><name sortKey="Shapiro, Craig N" sort="Shapiro, Craig N" uniqKey="Shapiro C" first="Craig N." last="Shapiro">Craig N. Shapiro</name><name sortKey="Wainwright, Robert B" sort="Wainwright, Robert B" uniqKey="Wainwright R" first="Robert B." last="Wainwright">Robert B. Wainwright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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